1196531-39-1
1196531-39-1
Chemical Structure
Sapitinib fumarate
Synonym(s): AZD-8931 fumarate
- CAS No.: 1196531-39-1
- Formula:C31H33ClFN5O11
- Molecular Weight:706.07
IUPAC Name: 2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide difumarate
InChIKey: LSXKPHWAKWZIKV-LVEZLNDCSA-N
SMILES: OC(/C=C/C(O)=O)=O.COC(C(OC1CCN(CC1)CC(NC)=O)=C2)=CC3=C2C(NC4=C(C(Cl)=CC=C4)F)=NC=N3.OC(/C=C/C(O)=O)=O
Biological Activity: Sapitinib fumarate is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.
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Sapitinib fumarate | Sapitinib fumarate is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively. | |||||||||||||||||||||
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Keywords
