1202000-62-1
1202000-62-1
Chemical Structure
Ivabradine sulfate
- CAS No.: 1202000-62-1
- Formula:C27H38N2O9S
- Molecular Weight:566.66
InChIKey: BTPJWGWDKZFLCT-ZMBIFBSDSA-N
SMILES: O=S(O)(O)=O.O=C(CC1=CC(OC)=C(OC)C=C1CC2)N2CCCN(C)C[C@@H]3C4=CC(OC)=C(OC)C=C4C3
Biological Activity: Ivabradine sulfate is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine sulfate reduces dose-dependently heart rate without modification of blood pressure. Ivabradine sulfate shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].
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Ivabradine sulfate | Ivabradine sulfate is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine sulfate reduces dose-dependently heart rate without modification of blood pressure. Ivabradine sulfate shows anticonvulsant, anti-ischaemic and anti-anginal activity. | |||||||||||||||||||||
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References
- [1]. Tardif JC, et al. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26(23):2529-36. [Content Brief]
- [2]. Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105. [Content Brief]
- [3]. Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512. [Content Brief]
- [4]. Du XJ, et al. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142(1):107-12. [Content Brief]
