1202401-59-9
Chemical Structure
PC-046
- CAS No.: 1202401-59-9
- Formula:C22H18N2O3
- Molecular Weight:358.39
IUPAC Name: 5-(4-methoxyphenyl)-2-(3-(3-methoxyphenyl)pyridin-4-yl)oxazole
InChIKey: CTNUOHRUVZXVHX-UHFFFAOYSA-N
SMILES: COC1=CC(C2=C(C=CN=C2)C3=NC=C(O3)C4=CC=C(C=C4)OC)=CC=C1
Biological Activity: PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice[1].
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PC-046 | PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice. | |||||||||||||||||||||
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Keywords
