1204408-27-4
1204408-27-4
Chemical Structure
HD-800
- CAS No.: 1204408-27-4
- Formula:C15H15N3O2
- Molecular Weight:269.30
IUPAC Name: N-(4-methoxyphenyl)-N,5-dimethylfuro[2,3-d]pyrimidin-4-amine
InChIKey: UVZUIESPIIIPQW-UHFFFAOYSA-N
SMILES: N=1C=NC(=C2C1OC=C2C)N(C3=CC=C(OC)C=C3)C
Biological Activity: HD-800 is a tubulin inhibitor with an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. HD-800 can be used to generate a radioactive tracer [11C]HD-800, and [11C]HD-800 can penetrate the blood-brain barrier and be used for positron emission tomography (PET) in various neurological diseases[1].
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HD-800 | HD-800 is a tubulin inhibitor with an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. HD-800 can be used to generate a radioactive tracer [11C]HD-800, and [11C]HD-800 can penetrate the blood-brain barrier and be used for positron emission tomography (PET) in various neurological diseases. | |||||||||||||||||||||
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References
Keywords
