1208829-24-6
Chemical Structure
MU876
- CAS No.: 1208829-24-6
- Formula:C24H18N6O3
- Molecular Weight:438.44
IUPAC Name: N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-3-phenyl-1H-pyrazol-5-yl)-5-phenylisoxazole-3-carboxamide
InChIKey: RANUMNIVHUDZPB-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(C2=CC=CC=C2)=C1)NC3=CC(C4=CC=CC=C4)=NN3C5=NC(C)=CC(N5)=O
Biological Activity: MU876 (Compound 32) is a MUS81 inhibitor with an IC50 of 0.5 μM. MU876 effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 sensitizes cancer cells to DNA-damaging agents, such as Cisplatin (HY-17394), through impairing their ability to repair DNA lesions. MU876 can be used for cancers chemotherapy research[1].
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MU876 | 97.00% | MU876 (Compound 32) is a MUS81 inhibitor with an IC50 of 0.5 μM. MU876 effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 sensitizes cancer cells to DNA-damaging agents, such as Cisplatin (HY-17394), through impairing their ability to repair DNA lesions. MU876 can be used for cancers chemotherapy research. | ||||||||||||||||||||
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