1209-71-8
Chemical Structure
γ-Eudesmol
Synonym(s): (+)-γ-Eudesmol
- CAS. Nr.: 1209-71-8
- Formula:C15H26O
- Molecular Weight:222.37
IUPAC Name: 2-((2R,4aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalen-2-yl)propan-2-ol
InChIKey: WMOPMQRJLLIEJV-IUODEOHRSA-N
SMILES: C[C@]12C(C[C@@H](CC1)C(C)(O)C)=C(CCC2)C
Biological Activity: γ-Eudesmol ((+)-γ-Eudesmol) is a mitochondrial-mediated apoptosis inducer. γ-Eudesmol binds mitochondrial membrane proteins, triggering depolarization of mitochondrial membrane potential and activating caspase cascades. γ-Eudesmol demonstrates cytotoxicity against multiple tumor cell lines (e.g., HepG2, B16-F10) with IC50 values ranging from 8.86-15.15 μg/mL. γ-Eudesmol is promising for research of cancers, such as hepatocellular carcinoma and melanoma[1][2][3].
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γ-Eudesmol | γ-Eudesmol ((+)-γ-Eudesmol) is a mitochondrial-mediated apoptosis inducer. γ-Eudesmol binds mitochondrial membrane proteins, triggering depolarization of mitochondrial membrane potential and activating caspase cascades. γ-Eudesmol demonstrates cytotoxicity against multiple tumor cell lines (e.g., HepG2, B16-F10) with IC50 values ranging from 8.86-15.15 μg/mL. γ-Eudesmol is promising for research of cancers, such as hepatocellular carcinoma and melanoma. | |||||||||||||||||||||
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References
- [1]. Chin YW, et al. Cytotoxic anticancer candidates from terrestrial plants. Anticancer Agents Med Chem. 2009 Oct;9(8):913-42. [Content Brief]
- [2]. Bomfim DS, et al. Eudesmol isomers induce caspase-mediated apoptosis in human hepatocellular carcinoma HepG2 cells. Basic Clin Pharmacol Toxicol. 2013 Nov;113(5):300-6. [Content Brief]
- [3]. Van Beek T A, et al. Essential oil of Amyris balsamifera[J]. Phytochemistry, 1989, 28(7): 1909-1911.
