1210501-46-4
Chemical Structure
CL-385319
- CAS No.: 1210501-46-4
- Formula:C15H19ClF4N2O
- Molecular Weight:354.77
IUPAC Name: 3-fluoro-N-(2-(piperidin-1-yl)ethyl)-5-(trifluoromethyl)benzamide hydrochloride
InChIKey: FEMIHMMAZDXYBI-UHFFFAOYSA-N
SMILES: O=C(NCCN1CCCCC1)C2=CC(C(F)(F)F)=CC(F)=C2.[H]Cl
Biological Activity: CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319[1].
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CL-385319 | 99.91% | CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319. | ||||||||||||||||||||
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