1216665-49-4
1216665-49-4
Chemical Structure
APY29
- CAS. Nr.: 1216665-49-4
- Formula:C17H16N8
- Molecular Weight:332.36
IUPAC Name: N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
InChIKey: WJNBSTLIALIIEW-UHFFFAOYSA-N
SMILES: C1(NC2=CC=C3N=CNC3=C2)=NC=CC(NC4=NNC(C5CC5)=C4)=N1
Biological Activity: APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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APY29 | 98.92% | APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.68
HY-18625VEGFR-2-IN-5 -
Similarity Score 0.68
HY-18625AVEGFR-2-IN-5 hydrochloride -
Similarity Score 0.64
HY-W771599ASC-69 -
Similarity Score 0.61
HY-185310MKI-2 -
Similarity Score 0.60
HY-182391MKI-3 -
Similarity Score 0.59
HY-161847HZ1 -
Similarity Score 0.58
HY-112273CD532 -
Similarity Score 0.58
HY-112273ACD532 hydrochloride -
Similarity Score 0.56
HY-100830NCB-0846 -
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