1217019-80-1
1217019-80-1
Chemical Structure
Azelastine-13C,d3
- CAS 番号: 1217019-80-1
- Formula:C2113CH21D3ClN3O
- Molecular Weight:385.91
IUPAC Name: (2R,3R,4R,5S,6R)-3-(acetamido-2,2,2-d3)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen phosphate
InChIKey: MBUVEWMHONZEQD-KQORAOOSSA-N
SMILES: O=C1N(C2CCN([13C]([2H])([2H])[2H])CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4
Biological Activity: Azelastine-13C,d3 is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
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Azelastine-13C,d3 | Azelastine-13C,d3 is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2. | |||||||||||||||||||||
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Azelastine-d3 | Azelastine-d3 is the deuterium labeled Azelastine (HY-B0462A). Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2. | |||||||||||||||||||||
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Azelastine | 99.92% | Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1(2):191-201. [Content Brief]
- [3]. Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8. [Content Brief]
- [4]. Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7(6): e00531. [Content Brief]
