1225141-73-0
1225141-73-0
Chemical Structure
D-G23
- CAS No.: 1225141-73-0
- Formula:C19H22N4O3
- Molecular Weight:354.40
IUPAC Name: 3-((2-((2,5-dimethoxyphenyl)amino)quinazolin-4-yl)amino)propan-1-ol
InChIKey: GIWRDZUFGSEQJA-UHFFFAOYSA-N
SMILES: OCCCNC1=C2C=CC=CC2=NC(NC3=CC(OC)=CC=C3OC)=N1
Biological Activity: D-G23 is a selective RAD52 inhibitor. D-G23 disrupts RAD52-mediated DNA repair pathways and suppresses the growth of BRCA1- and BRCA2-deficient cancer cells. D-G23 is promising for research of homologous recombination-related cancers, such as hereditary breast cancer and ovarian cancer caused by BRCA1/2 mutations[1].
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D-G23 | D-G23 is a selective RAD52 inhibitor. D-G23 disrupts RAD52-mediated DNA repair pathways and suppresses the growth of BRCA1- and BRCA2-deficient cancer cells. D-G23 is promising for research of homologous recombination-related cancers, such as hereditary breast cancer and ovarian cancer caused by BRCA1/2 mutations. | |||||||||||||||||||||
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References
Keywords
