1225177-95-6
1225177-95-6
Chemical Structure
Covidcil-19
- CAS No.: 1225177-95-6
- Formula:C16H14N4O2
- Molecular Weight:294.31
InChIKey: ATKIOCNKZKNVQS-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NC2=NC(NC)=C3C=CC=CC3=N2)=CC=C1)O
Biological Activity: Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation[1].
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Covidcil-19 | Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation. | |||||||||||||||||||||
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