1227678-26-3
1227678-26-3
Chemical Structure
Agerafenib hydrochloride
Synonym(s): CEP-32496 hydrochloride; RXDX-105 hydrochloride
- CAS No.: 1227678-26-3
- Formula:C24H23ClF3N5O5
- Molecular Weight:553.92
IUPAC Name: 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride
InChIKey: XCZIYUDQUDWQHI-UHFFFAOYSA-N
SMILES: O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)NC2=CC=CC(OC3=C(C=C(OC)C(OC)=C4)C4=NC=N3)=C2.[H]Cl
Biological Activity: Agerafenib hydrochloride is a highly potent and orally efficacious inhibitor of BRAFV600E with a Kd of 14 nM.
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Agerafenib hydrochloride | Agerafenib hydrochloride is a highly potent and orally efficacious inhibitor of BRAFV600E with a Kd of 14 nM. | |||||||||||||||||||||
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