1238689-36-5
1238689-36-5
Chemical Structure
JNJ-42905343
- CAS No.: 1238689-36-5
- Formula:C20H15FN4O4
- Molecular Weight:394.36
IUPAC Name: 1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-oxo-1,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid
InChIKey: GXDKPOPOLNGUNT-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C(NC2=C3C=C(OC4=C(C)C=CC=C4C)C(F)=C2)=NC3=O)N=C1)O
Biological Activity: JNJ-42905343 is an orally active and highly selective prolyl hydroxylase (PHD1/2/3) inhibitor with pKI values of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3, respectively. JNJ-42905343 is promising for research of functional iron deficiency (FID) and anemia of chronic disease (ACD)[1].
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JNJ-42905343 | JNJ-42905343 is an orally active and highly selective prolyl hydroxylase (PHD1/2/3) inhibitor with pKI values of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3, respectively. JNJ-42905343 is promising for research of functional iron deficiency (FID) and anemia of chronic disease (ACD). | |||||||||||||||||||||
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