123884-00-4
Chemical Structure
Dolastatin 15
Synonym(s): DLS 15
- CAS No.: 123884-00-4
- Formula:C45H68N6O9
- Molecular Weight:837.06
IUPAC Name: (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinate
InChIKey: LQKSHSFQQRCAFW-CCVNJFHASA-N
SMILES: O=C(N(C1=O)[C@H](C(OC)=C1)CC2=CC=CC=C2)[C@H](C(C)C)OC([C@H](CCC3)N3C([C@H](CCC4)N4C([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)=O)=O
Biological Activity: Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin[1][2][3].
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Dolastatin 15 | Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin. | |||||||||||||||||||||
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- [1]. Bai R, et al. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45. [Content Brief]
- [2]. Sato M, et al. A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells. Int J Oncol. 2007 Jun;30(6):1453-9. [Content Brief]
- [3]. Gianolio DA, et al. Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates. Cancer Chemother Pharmacol. 2012 Sep;70(3):439-49. [Content Brief]
Keywords
