1243583-88-1
1243583-88-1
Chemical Structure
CAY10669
- CAS No.: 1243583-88-1
- Formula:C20H22O4
- Molecular Weight:326.39
IUPAC Name: (Z)-2-hydroxy-6-(4-(pentyloxy)styryl)benzoic acid
InChIKey: JZTUSBQKQHUSQE-FLIBITNWSA-N
SMILES: OC1=CC=CC(/C=C\C2=CC=C(C=C2)OCCCCC)=C1C(O)=O
Biological Activity: CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM[1]. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CAY10669 | 99.9% | CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells. | ||||||||||||||||||||
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References
- [1]. Ghizzoni M, et al., Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative. Bioorg Med Chem. 2010 Aug 15;18(16):5826-34. [Content Brief]
- [2]. Farr GH 3rd, et al., A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2020 Oct 15;10(1):29. [Content Brief]
- [3]. Christensen MD, et al., An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA. J Control Release. 2018 Sep 28;286:210-223. [Content Brief]
Keywords
