1247000-76-5
Chemical Structure
(1E)-CFI-400437 dihydrochloride
- CAS No.: 1247000-76-5
- Formula:C29H30Cl2N6O2
- Molecular Weight:565.49
IUPAC Name: (Z)-5-methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one dihydrochloride
InChIKey: XQZOWXHJNLSRCM-FFJVXDJSSA-N
SMILES: Cl[H].Cl[H].COC1=CC(/C2=C/C3=CC4=C(C(/C=C/C5=CC=C(N=C5)N6CCN(CC6)C)=NN4)C=C3)=C(C=C1)NC2=O
Biological Activity: (1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(1E)-CFI-400437 dihydrochloride | 98.03% | (1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity. | ||||||||||||||||||||
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