1254979-66-2
1254979-66-2
Chemical Structure
JNJ-46356479
- CAS. Nr.: 1254979-66-2
- Formula:C22H22F5N5
- Molecular Weight:451.44
IUPAC Name: 3-(cyclopropylmethyl)-7-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
InChIKey: BNJUYVSEWGRELC-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(F)=C1)N2CCN(CC2)CC3=C(C4=NN=C(N4C=C3)CC5CC5)C(F)(F)F
Biological Activity: JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo[1].
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JNJ-46356479 | 99.77% | JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo. | ||||||||||||||||||||
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References
- [1]. Cid JM, et al. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM). J Med Chem. 2016;59(18):8495-8507. [Content Brief]
