1257235-99-6
Chemical Structure
NU5455
- CAS No.: 1257235-99-6
- Formula:C34H33N3O5S
- Molecular Weight:595.71
IUPAC Name: N-(6-(2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl)-N-methyl-2-morpholinoacetamide
InChIKey: NYHCXQIUWIEKQC-UHFFFAOYSA-N
SMILES: CN(C1=CC=C2SC3=C(C4=C(OC(N5CC(CC6)OC6C5)=CC7=O)C7=CC=C4)C=CC=C3C2=C1)C(CN8CCOCC8)=O
Biological Activity: NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NU5455 | 98.81% | NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect. | ||||||||||||||||||||
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