1260071-76-8
Chemical Structure
DMBT
- CAS No.: 1260071-76-8
- Formula:C30H38O17
- Molecular Weight:670.61
InChIKey: ROEGNYZSLMABKO-FNYGWCGHSA-N
SMILES: O=C(C1=C(C(OC)=CC=C1)OC)OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@@H]2O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)COC(C4=C(C(OC)=CC=C4)OC)=O
Biological Activity: DMBT is an orally effective anti-tumor metastasis and anti-angiogenesis agent. DMBT downregulates key molecules such as EGFR/p-Akt/HIF-1α/VEGF/MMP-9, inhibits the HIF-1α/VE-cadherin (cadherin)/MMPs and Nrf2/HO-1 signaling pathways, and reduces hypoxia-induced ROS levels as well as the secretion and activity of MMP-9. DMBT inhibits hypoxia-induced vasculogenic mimicry, cancer cell migration, invasion and metastasis, and exhibits no obvious cytotoxicity to normal cells. DMBT reduces the area of laser-induced choroidal neovascularization lesions. DMBT can be used in studies related to breast cancer, melanoma and macular degeneration[1][2][3][4].
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DMBT | DMBT is an orally effective anti-tumor metastasis and anti-angiogenesis agent. DMBT downregulates key molecules such as EGFR/p-Akt/HIF-1α/VEGF/MMP-9, inhibits the HIF-1α/VE-cadherin (cadherin)/MMPs and Nrf2/HO-1 signaling pathways, and reduces hypoxia-induced ROS levels as well as the secretion and activity of MMP-9. DMBT inhibits hypoxia-induced vasculogenic mimicry, cancer cell migration, invasion and metastasis, and exhibits no obvious cytotoxicity to normal cells. DMBT reduces the area of laser-induced choroidal neovascularization lesions. DMBT can be used in studies related to breast cancer, melanoma and macular degeneration. | |||||||||||||||||||||
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References
- [1]. Li S, et al. Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Dec;96:982-992. [Content Brief]
- [2]. Tang L, et al. Inhibition of invasion and metastasis by DMBT, a novel trehalose derivative, through Akt/GSK-3β/β-catenin pathway in B16BL6 cells. Chem Biol Interact. 2014 Oct 5;222:7-17. [Content Brief]
- [3]. Tang L, et al. Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Akt pathway in MDA-MB-231 breast cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Jun;56:204-13. [Content Brief]
- [4]. Chen S, et al. Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway. Molecular and cellular biochemistry. 2018 Nov;448(1-2):225-235. [Content Brief]
