1268264-10-3
Chemical Structure
Zgwatinib
Synonym(s): SOMG-833
- CAS. Nr.: 1268264-10-3
- Formula:C22H22F3N5O2
- Molecular Weight:445.44
IUPAC Name: 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine
InChIKey: JIYPGFPFAVEPFX-UHFFFAOYSA-N
SMILES: O=[N+]([O-])C1=CC(CNC2=C3C=C(C=NC3=CC(C(F)(F)F)=C2)N4CCN(CC4)C)=CC=C1
Biological Activity: Zgwatinib (SOMG-833) is a potent, selective, and ATP-competitive c-MET inhibitor, with an IC50 of 0.93 nM against c-MET, over 10,000-fold more potent compared with 19 tyrosine kinases (including c-MET family members and highly homologous kinases). Zgwatinib potently inhibits c-MET-driven cell proliferation. Zgwatinib as a potential candidate agent for c-MET-driven human cancers research[1].
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Zgwatinib | Zgwatinib (SOMG-833) is a potent, selective, and ATP-competitive c-MET inhibitor, with an IC50 of 0.93 nM against c-MET, over 10,000-fold more potent compared with 19 tyrosine kinases (including c-MET family members and highly homologous kinases). Zgwatinib potently inhibits c-MET-driven cell proliferation. Zgwatinib as a potential candidate agent for c-MET-driven human cancers research. | |||||||||||||||||||||
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