1277165-15-7
Chemical Structure
GSK 1842799 hydrochloride
- CAS No.: 1277165-15-7
- Formula:C20H30Cl2F3N3O2S
- Molecular Weight:504.44
InChIKey: BOSBUEYDEZTEKA-TXEPZDRESA-N
SMILES: OC[C@](N)(C1=NN=C(C2=CC(C(F)(F)F)=C(C=C2)OCCCCCCCC)S1)C.Cl.Cl
Biological Activity: GSK 1842799 hydrochloride is a selective S1P1 receptor agonist with potent agonist activity and exceptional selectivity over S1P3. GSK 1842799 hydrochloride demonstrates good oral bioavailability and rapid conversion to its active phosphorylated form. GSK 1842799 hydrochloride significantly reduces blood lymphocyte counts in vivo following oral administration. GSK 1842799 hydrochloride has shown efficacy comparable to FTY720 in the mouse EAE model of multiple sclerosis.
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GSK 1842799 hydrochloride | GSK 1842799 hydrochloride is a selective S1P1 receptor agonist with potent agonist activity and exceptional selectivity over S1P3. GSK 1842799 hydrochloride demonstrates good oral bioavailability and rapid conversion to its active phosphorylated form. GSK 1842799 hydrochloride significantly reduces blood lymphocyte counts in vivo following oral administration. GSK 1842799 hydrochloride has shown efficacy comparable to FTY720 in the mouse EAE model of multiple sclerosis. | |||||||||||||||||||||
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Keywords
