128914-47-6
128914-47-6
Chemical Structure
17-HETE
- CAS. Nr.: 128914-47-6
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (5Z,8Z,11Z,14Z)-17-hydroxyicosa-5,8,11,14-tetraenoic acid
InChIKey: OPPIPPRXLIDJKN-JPURVOHMSA-N
SMILES: CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O
Biological Activity: 17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].
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17-HETE | 17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy. | |||||||||||||||||||||
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References
- [1]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [Content Brief]
- [2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
Keywords
