129731-10-8
129731-10-8
Chemical Structure
Vorozole
Synonym(s): (+)-Vorozole; R83842
- CAS No.: 129731-10-8
- Formula:C16H13ClN6
- Molecular Weight:324.77
IUPAC Name: (S)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1-methyl-1H-benzo[d][1,2,3]triazole
InChIKey: XLMPPFTZALNBFS-INIZCTEOSA-N
SMILES: CN1N=NC2=CC=C([C@H](C3=CC=C(Cl)C=C3)N4N=CN=C4)C=C21
Biological Activity: Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3].
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Vorozole | Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer. | |||||||||||||||||||||
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References
- [1]. Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):617-21. [Content Brief]
- [2]. Wiseman LR, et al. Vorozole. Drugs Aging. 1997 Sep;11(3):245-50; discussion 251-2. [Content Brief]
- [3]. Lubet RA,et al. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis. 1998 Aug;19(8):1345-51. [Content Brief]
Keywords
