130007-52-2
Chemical Structure
L-669083
- CAS 番号: 130007-52-2
- Formula:C29H29IN4O5S
- Molecular Weight:672.53
IUPAC Name: 3-(3-((4-azidophenyl)sulfonyl)-1-(4-hydroxy-3-iodobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid
InChIKey: AKCMQYDDRKIENA-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NC1=CC=C(S(=O)(C2=C(CC(C)(C)C(O)=O)N(CC3=CC=C(C(I)=C3)O)C4=C2C=C(C(C)C)C=C4)=O)C=C1
Biological Activity: L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors.
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L-669083 | L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors. | |||||||||||||||||||||
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