1303609-30-4
Chemical Structure
MI-888 TFA
- CAS No.: 1303609-30-4
- Formula:C30H33Cl2F4N3O5
- Molecular Weight:662.50
IUPAC Name: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,3R)-3-hydroxy-3-methylcyclobutyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide 2,2,2-trifluoroacetate
InChIKey: ALTIHMRCJFNFEA-KJUKZGQDSA-N
SMILES: O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5C[C@](C)(O)C5.O=C(O)C(F)(F)F
Biological Activity: MI-888 (TFA) is an orally active MDM2-p53 interaction inhibitor with a Ki of 0.44 nM. MI-888 (TFA) can achieve rapid, complete, and sustained tumor regression in a xenograft mouse model of cancer[1].
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MI-888 TFA | MI-888 (TFA) is an orally active MDM2-p53 interaction inhibitor with a Ki of 0.44 nM. MI-888 (TFA) can achieve rapid, complete, and sustained tumor regression in a xenograft mouse model of cancer. | |||||||||||||||||||||
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Keywords
