1312201-00-5
1312201-00-5
Chemical Structure
HA155
- CAS No.: 1312201-00-5
- Formula:C24H19BFNO5S
- Molecular Weight:463.29
IUPAC Name: (Z)-(4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid
InChIKey: BRWUZCBSWABPMR-XKZIYDEJSA-N
SMILES: O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O.[(Z)]
Biological Activity: HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HA155 | 98.50% | HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM. | ||||||||||||||||||||
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References
- [1]. Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112(5):2593-603. [Content Brief]
- [2]. Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54(13):4619-26. [Content Brief]
- [3]. Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286(40):34654-63. [Content Brief]
Keywords
