1314021-57-2
1314021-57-2
Chemical Structure
ARQ 069
- CAS No.: 1314021-57-2
- Formula:C18H15N3
- Molecular Weight:273.33
IUPAC Name: (S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine
InChIKey: BMOQBIIJPJVMDI-INIZCTEOSA-N
SMILES: NC1=NC=C2C[C@@H](C3=CC=CC=C3)C4=CC=CC=C4C2=N1
Biological Activity: ARQ 069, an analog of ARQ 523, inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC50s of 0.84 μM and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner[1].
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ARQ 069 | ARQ 069, an analog of ARQ 523, inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC50s of 0.84 μM and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner. | |||||||||||||||||||||
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