132031-81-3
132031-81-3
Chemical Structure
NP-252
- CAS No.: 132031-81-3
- Formula:C26H35N3O5
- Molecular Weight:469.57
IUPAC Name: octyl 5-(cyclopropylcarbamoyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
InChIKey: IAWVGADTHVEXRD-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)NC(C)=C(C1C2=C([N+]([O-])=O)C=CC=C2)C(NC3CC3)=O)OCCCCCCCC
Biological Activity: NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats[1].
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NP-252 | NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats. | |||||||||||||||||||||
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References
- [1]. Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[(cyclopropylamino)-carbonyl]-1,4-dihydro-2,6-dimethyl-4-(2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43(8):847-51. [Content Brief]
