132036-88-5
132036-88-5
Chemical Structure
Ramosetron
Synonym(s): YM060 free base
- CAS No.: 132036-88-5
- Formula:C17H17N3O
- Molecular Weight:279.34
IUPAC Name: (R)-(1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-6-yl)methanone
InChIKey: NTHPAPBPFQJABD-LLVKDONJSA-N
SMILES: O=C([C@H]1CC2=C(N=CN2)CC1)C3=CN(C)C4=CC=CC=C34
Biological Activity: Ramosetron (YM060 free base) is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron is promising for research of irritable bowel syndrome with diarrhea[1][2][3][4].
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Ramosetron | Ramosetron (YM060 free base) is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron is promising for research of irritable bowel syndrome with diarrhea. | |||||||||||||||||||||
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Ramosetron-d3 hydrochloride | Ramosetron-d3 (hydrochloride) is the deuterium labeled Ramosetron hydrochloride. | |||||||||||||||||||||
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References
- [1]. http://www.drugsupdate.com/generic/view/1111
- [2]. Yasuda M, et al. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol. 2013 Mar;168(6):1388-400. [Content Brief]
- [3]. Kojima SI, et al. Investigation of 5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. [Content Brief]
- [4]. Fukudo S, et al. Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women. Gastroenterology. 2016 Feb;150(2):358-66.e8. [Content Brief]
