132523-84-3
Chemical Structure
Tedisamil dihydrochloride
Synonym(s): KC-8857 dihydrochloride
- CAS No.: 132523-84-3
- Formula:C19H34Cl2N2
- Molecular Weight:361.39
InChIKey: NXXZICGFHYJPGE-ULEYXFCOSA-N
SMILES: [C@@H](CN1CC2CC2)(C3)C4(CCCC4)[C@@H](C1)CN3CC5CC5.Cl.Cl
Biological Activity: Tedisamil (KC-8857) dihydrochloride is an antiarrhythmic compound with important biological activities. Tedisamil dihydrochloride exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil dihydrochloride inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil dihydrochloride has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models[1].
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Tedisamil dihydrochloride | Tedisamil (KC-8857) dihydrochloride is an antiarrhythmic compound with important biological activities. Tedisamil dihydrochloride exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil dihydrochloride inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil dihydrochloride has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models. | |||||||||||||||||||||
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Keywords
