133084-52-3
Chemical Structure
Lyngbyatoxin B
- No. CAS: 133084-52-3
- Formula:C27H39N3O3
- Molecular Weight:453.62
IUPAC Name: 9-(6-hydroxy-3,7-dimethylocta-1,7-dien-3-yl)-5-(hydroxymethyl)-2-isopropyl-1-methyl-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one
InChIKey: RLQWNZUFDRUTMZ-UHFFFAOYSA-N
SMILES: O=C(NC(CO)C1)C(C(C)C)N(C)C2=CC=C(C(C)(C=C)CCC(O)C(C)=C)C3=C2C1=CN3
Biological Activity: Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products.
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Lyngbyatoxin B | Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products. | |||||||||||||||||||||
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