1338483-10-5
Chemical Structure
AM-9635
- CAS No.: 1338483-10-5
- Formula:C19H14F2N8
- Molecular Weight:392.36
IUPAC Name: (S)-4-amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile
InChIKey: QLWGSXWLXIBFPF-JTQLQIEISA-N
SMILES: N#CC(C(N[C@H](C(N(C1=CN=CC(F)=C1)C2=C3)=NC2=CC=C3F)C)=NC=N4)=C4N
Biological Activity: AM-9635 is a selective PI3Kδ inhibitor with oral bioavailability, good in vitro and in vivo activity and pharmacodynamic properties. AM-9635 inhibits PI3Kδ-dependent B cell receptor-mediated AKT phosphorylation and suppresses the production of specific IgG and IgM antibodies in rats immunized with Aplysia leocyanin (KLH).
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AM-9635 | AM-9635 is a selective PI3Kδ inhibitor with oral bioavailability, good in vitro and in vivo activity and pharmacodynamic properties. AM-9635 inhibits PI3Kδ-dependent B cell receptor-mediated AKT phosphorylation and suppresses the production of specific IgG and IgM antibodies in rats immunized with Aplysia leocyanin (KLH). | |||||||||||||||||||||
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Keywords
