134520-88-0
Chemical Structure
CGP-45688
- CAS No.: 134520-88-0
- Formula:C16H10N6
- Molecular Weight:286.29
IUPAC Name: 4,4'-((2H-tetrazol-2-yl)methylene)dibenzonitrile
InChIKey: PQSGESDQXVWRGN-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C(C2=CC=C(C=C2)C#N)N3N=CN=N3)C=C1
Biological Activity: CGP-45688 is an orally active non-steroidal aromatase inhibitor with an ED50 of 30-100 μg/kg. CGP-45688 can reduce the level of estrogen in the body, thereby inhibiting the growth of estrogen-dependent tumors. CGP-45688 inhibits the growth of estrogen-dependent breast tumors in rat models. CGP-45688 disrupts the ovarian cycle and inhibits the weight of the uterus. CGP-45688 can be used for the study of breast cancer[1].
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CGP-45688 | CGP-45688 is an orally active non-steroidal aromatase inhibitor with an ED50 of 30-100 μg/kg. CGP-45688 can reduce the level of estrogen in the body, thereby inhibiting the growth of estrogen-dependent tumors. CGP-45688 inhibits the growth of estrogen-dependent breast tumors in rat models. CGP-45688 disrupts the ovarian cycle and inhibits the weight of the uterus. CGP-45688 can be used for the study of breast cancer. | |||||||||||||||||||||
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