1346169-92-3
Chemical Structure
MPT0B392
- CAS No.: 1346169-92-3
- Formula:C19H20N2O6S
- Molecular Weight:404.44
IUPAC Name: 6-methoxy-2-((3,4,5-trimethoxyphenyl)sulfonyl)quinolin-5-amine
InChIKey: RBBRZMLZQCYQJM-UHFFFAOYSA-N
SMILES: NC1=C2C(N=C(S(=O)(C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C2)=CC=C1OC
Biological Activity: MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line[1].
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MPT0B392 | 99.63% | MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. | ||||||||||||||||||||
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MPT0B392 (Standard) | ≥98% | MPT0B392 (Standard) is the analytical standard of MPT0B392 (HY-101287). This product is intended for research and analytical applications. MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. | ||||||||||||||||||||
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Similarity Score 0.68
HY-124083MPT0B214 -
Similarity Score 0.58
HY-146863Tubulin polymerization-IN-10 -
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HY-124793AGAK inhibitor 49 hydrochloride -
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HY-124793GAK inhibitor 49 -
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HY-169789PKN3-IN-1 -
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HY-122186SGC-GAK-1 -
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