134892-42-5
Chemical Structure
AGN-190851
- CAS No.: 134892-42-5
- Formula:C11H14BrN5
- Molecular Weight:296.17
IUPAC Name: 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydroquinoxalin-6-amine
InChIKey: CETMNKCDAHCKRC-UHFFFAOYSA-N
SMILES: BrC1=C2NCCNC2=CC=C1/N=C3NCCN/3
Biological Activity: AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition[1][2].
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AGN-190851 | AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition. | |||||||||||||||||||||
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References
- [1]. Brooks DP, et al. The water diuretic effect of the alpha-2 adrenoceptor agonist, AGN 190851, is species-dependent. J Pharmacol Exp Ther. 1991;259(3):1277-1282. [Content Brief]
- [2]. Yang PC, et al. Farrowing induction with a combination of prostaglandin F(2alpha) and a peripherally acting alpha(2)--adrenergic agonist AGN 190851 and a combination of prostaglandin F(2alpha) and oxytocin. Theriogenology. 1996 Nov 1;46(7):1289-93. [Content Brief]
