135135-87-4
135135-87-4
Chemical Structure
DuP 734
- CAS No.: 135135-87-4
- Formula:C17H23BrFNO
- Molecular Weight:356.27
IUPAC Name: 2-(1-(cyclopropylmethyl)piperidin-4-yl)-1-(4-fluorophenyl)ethan-1-one hydrobromide
InChIKey: QLZIAKMYJFJBKA-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(CC2CCN(CC3CC3)CC2)=O)C=C1.[H]Br
Biological Activity: DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics[1][2][3].
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DuP 734 | 98.82% | DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics. | ||||||||||||||||||||
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References
- [1]. L Cook, et al. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- Oxoethyl)piperidine HBr], a Potential Antipsychotic Agent: Preclinical Behavioral Effects. J Pharmacol Exp Ther. 1992 Dec;263(3):1159-66. [Content Brief]
- [2]. M Watanabe, et al. [3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) Piperidine HBr (DuP 734). A Selective Ligand for Sigma Receptors in Mouse Brain in Vivo. J Pharmacol Exp Ther. 1993 Sep;266(3):1541-8. [Content Brief]
- [3]. R P Kapil, et al. Dose and Species Dependent Pharmacokinetics of a Novel Sigma Receptor Antagonist, DuP 734. Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):3-20. [Content Brief]
Keywords
