1353546-86-7
Chemical Structure
Orismilast
Synonym(s): LEO-32731
- CAS. Nr.: 1353546-86-7
- Formula:C19H15Cl2F2NO7S
- Molecular Weight:510.29
IUPAC Name: 3,5-dichloro-4-(2-(4-(difluoromethoxy)-1',1'-dioxido-2',3',5',6'-tetrahydrospiro[benzo[d][1,3]dioxole-2,4'-thiopyran]-7-yl)-2-oxoethyl)pyridine 1-oxide
InChIKey: ZININGNRPUGNSL-UHFFFAOYSA-N
SMILES: O=S1(CCC2(OC3=C(C=CC(C(CC4=C(C=[N+](C=C4Cl)[O-])Cl)=O)=C3O2)OC(F)F)CC1)=O
Biological Activity: Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants[1][2].
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Orismilast | 99.88% | Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants. | ||||||||||||||||||||
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- [1]. Nielsen,et al.Preparation of benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors.WO2011160632A1.
- [2]. Jonathan I Silverberg, et al. Pharmacology of orismilast, a potent and selective PDE4 inhibitor. J Eur Acad Dermatol Venereol. 2023 Apr;37(4):721-729. [Content Brief]
Keywords
