1354060-46-0
1354060-46-0
Chemical Structure
AGN 225660
- CAS No.: 1354060-46-0
- Formula:C20H27ClN2O3
- Molecular Weight:378.89
InChIKey: NTKCCANMCAOSKM-UHFFFAOYSA-N
SMILES: O=C(CCC1=NN(CC2=CC(Cl)=CC=C2OCC(CC)CC)C(C)=C1)O
Biological Activity: AGN 225660 is a multi-prostanoid receptor antagonist with human IC50 values of 70, 70, 5, 220 and 180 nM for EP1, EP4, TP, DP1, FP. AGN 225660 inhibits secretion of RANTES, IL-8, MCP-1, IL-12p70, and IL-23. AGN 225660 exhibits good ocular bioavailability and reduces ocular inflammation linked to phacoemulsification surgery and uveitis[1].
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AGN 225660 | AGN 225660 is a multi-prostanoid receptor antagonist with human IC50 values of 70, 70, 5, 220 and 180 nM for EP1, EP4, TP, DP1, FP. AGN 225660 inhibits secretion of RANTES, IL-8, MCP-1, IL-12p70, and IL-23. AGN 225660 exhibits good ocular bioavailability and reduces ocular inflammation linked to phacoemulsification surgery and uveitis. | |||||||||||||||||||||
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References
Keywords
