1354787-69-1
1354787-69-1
Chemical Structure
DC41
- CAS No.: 1354787-69-1
- Formula:C37H34ClN5O4S
- Molecular Weight:680.21
IUPAC Name: (S)-N-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)-5-(4-mercapto-4-methylpentanamido)-1H-indole-2-carboxamide
InChIKey: WVQLZKRXHPZHLA-JOCHJYFZSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC(NC(CCC(C)(S)C)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Biological Activity: DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].
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DC41 | DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. | |||||||||||||||||||||
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References
- [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [Content Brief]
- [2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21. [Content Brief]
