136470-78-5
136470-78-5
Chemical Structure
Abacavir
- CAS No.: 136470-78-5
- Formula:C14H18N6O
- Molecular Weight:286.34
IUPAC Name: ((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
InChIKey: MCGSCOLBFJQGHM-SCZZXKLOSA-N
SMILES: NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1
Biological Activity: Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Abacavir | 99.88% | Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity. | ||||||||||||||||||||
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Abacavir (Standard) | ≥98% | Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity. | ||||||||||||||||||||
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rel-Abacavir-d4 | 98.3% | rel-Abacavir-d4 is the deuterium labeled rel-Abacavir. | ||||||||||||||||||||
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Abacavir-d4 | Abacavir-d4 is the deuterium labeled Abacavir. Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI). | |||||||||||||||||||||
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References
- [1]. Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. [Content Brief]
- [2]. Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. [Content Brief]
- [3]. Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. [Content Brief]
