1374107-54-6
1374107-54-6
Chemical Structure
THK-5117
- CAS No.: 1374107-54-6
- Formula:C19H19FN2O2
- Molecular Weight:326.36
IUPAC Name: 1-fluoro-3-((2-(4-(methylamino)phenyl)quinolin-6-yl)oxy)propan-2-ol
InChIKey: QXGZMQJLUUBGMN-UHFFFAOYSA-N
SMILES: OC(COC1=CC=C2N=C(C3=CC=C(NC)C=C3)C=CC2=C1)CF
Biological Activity: THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
THK-5117 | 98.52% | THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
