137881-27-7
Chemical Structure
INH2BP
- CAS No.: 137881-27-7
- Formula:C9H6INO2
- Molecular Weight:287.05
IUPAC Name: 6-amino-5-iodo-2H-chromen-2-one
InChIKey: WWRAFPGUBABZSD-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(I)C(N)=CC=C2O1
Biological Activity: INH2BP is a poly(ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities. INH2BP reduces the production of intracellular reactive oxygen species (ROS), modulates the expression of apoptosis-related proteins such as Bax, Bcl-2 and cleaved caspase-3 and enhances cell survival through the activation of the ERK1/2 and p38 MAPK signaling pathways. INH2BP is promising for research of cardiovascular diseases[1].
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INH2BP | INH2BP is a poly(ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities. INH2BP reduces the production of intracellular reactive oxygen species (ROS), modulates the expression of apoptosis-related proteins such as Bax, Bcl-2 and cleaved caspase-3 and enhances cell survival through the activation of the ERK1/2 and p38 MAPK signaling pathways. INH2BP is promising for research of cardiovascular diseases. | |||||||||||||||||||||
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Keywords
