1380317-28-1
Chemical Structure
Momelotinib dihydrochloride
- CAS No.: 1380317-28-1
- Formula:C23H24Cl2N6O2
- Molecular Weight:487.38
IUPAC Name: N-(cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide dihydrochloride
InChIKey: IPNATXQRPWRHKD-UHFFFAOYSA-N
SMILES: O=C(NCC#N)C(C=C1)=CC=C1C2=NC(NC(C=C3)=CC=C3N4CCOCC4)=NC=C2.Cl.Cl
Biological Activity: Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis[1].
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Momelotinib dihydrochloride | 99.56% | Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis. | ||||||||||||||||||||
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Keywords
