1381459-14-8
1381459-14-8
Chemical Structure
ARN1468
- CAS No.: 1381459-14-8
- Formula:C16H17F3N4O2
- Molecular Weight:354.33
IUPAC Name: tetramethyl 4,4'-((1,4,10-trioxa-7,13-diazacyclopentadecane-7,13-diyl)bis(5-methoxybenzofuran-6,2-diyl))diisophthalate
InChIKey: OOUGXIZAHWLQEM-UHFFFAOYSA-N
SMILES: O=C(C1=C(N(C2=CC=C(OC(F)(F)F)C=C2)N=C1)N)C3CCNCC3
Biological Activity: ARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ARN1468 | 98.96% | ARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM. | ||||||||||||||||||||
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