1395048-49-3
1395048-49-3
Chemical Structure
M-110
- CAS. Nr.: 1395048-49-3
- Formula:C22H28ClN5O3
- Molecular Weight:445.94
IUPAC Name: (E)-N'-(1-(4-chloro-2-hydroxyphenyl)propylidene)-2-((3-morpholinopropyl)amino)isonicotinohydrazide
InChIKey: FXXCNYVQIONABS-LGUFXXKBSA-N
SMILES: O=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC(NCCCN3CCOCC3)=NC=C2
Biological Activity: M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM[1].
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M-110 | 99.05% | M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM. | ||||||||||||||||||||
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