1400687-19-5
Chemical Structure
JAK1/3-IN-1
- CAS No.: 1400687-19-5
- Formula:C22H28N6O2
- Molecular Weight:408.51
IUPAC Name: 4-(((1R,3S)-3-amino-2,2,3-trimethylcyclopentyl)amino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
InChIKey: VPEQKGXRQZTIES-VGSWGCGISA-N
SMILES: N(C=1C=2N(C=C(C2)C=3C=CC(OC)=NC3)N=CC1C(N)=O)[C@H]4C(C)(C)[C@@](C)(N)CC4
Biological Activity: JAK1/3-IN-1 is a selective, orally active JAK1/3 inhibitor with IC50 values of 1.9 nM and 0.9 nM, respectively. JAK1/3-IN-1 significantly reduces the mean arterial blood pressure and significantly increases the heart rate in rabbits. JAK1/3-IN-1 decreases the mean arterial blood pressure in conscious telemetered rats and induces lethal cardiovascular effects[1].
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JAK1/3-IN-1 | JAK1/3-IN-1 is a selective, orally active JAK1/3 inhibitor with IC50 values of 1.9 nM and 0.9 nM, respectively. JAK1/3-IN-1 significantly reduces the mean arterial blood pressure and significantly increases the heart rate in rabbits. JAK1/3-IN-1 decreases the mean arterial blood pressure in conscious telemetered rats and induces lethal cardiovascular effects. | |||||||||||||||||||||
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