1401731-54-1
1401731-54-1
Chemical Structure
MRT00033659
- CAS No.: 1401731-54-1
- Formula:C15H14N4O
- Molecular Weight:266.30
IUPAC Name: N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide
InChIKey: YFBPGSDPFRCNOY-UHFFFAOYSA-N
SMILES: CC1=NNC2=NC=C(C=C21)C3=CC=CC(NC(C)=O)=C3
Biological Activity: MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1].
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MRT00033659 | 98.40% | MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation. | ||||||||||||||||||||
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