1430720-10-7
1430720-10-7
Chemical Structure
HS-438
- CAS No.: 1430720-10-7
- Formula:C17H17N3O3S
- Molecular Weight:343.40
IUPAC Name: 1-(2-hydroxyethyl)-3-(6-(2-methoxyphenyl)benzo[d]thiazol-2-yl)urea
InChIKey: LAAHHHDILCOULN-UHFFFAOYSA-N
SMILES: O=C(NCCO)NC1=NC2=CC=C(C=C2S1)C3=CC=CC=C3OC
Biological Activity: HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML)[1].
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HS-438 | HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML). | |||||||||||||||||||||
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