1431368-48-7
1431368-48-7
Chemical Structure
GSK-LSD1
- CAS No.: 1431368-48-7
- Formula:C14H20N2
- Molecular Weight:216.32
IUPAC Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine
InChIKey: BASFYRLYJAZPPL-UONOGXRCSA-N
SMILES: C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1
Biological Activity: GSK-LSD1, a chemical probe, is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis[1][2][3].
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GSK-LSD1 | GSK-LSD1, a chemical probe, is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis. | |||||||||||||||||||||
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References
- [1]. Ramms B, et al. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 Dec 1;71(12):2513-2529. [Content Brief]
- [2]. Hong KS, et al. GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro. Signal Transduct Target Ther. 2020 Nov 17;5(1):267. [Content Brief]
- [3]. Alsaqer SF, et al. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget. 2017 Jul 27;8(43):73372-73386. [Content Brief]
Keywords
