1433286-70-4
1433286-70-4
Chemical Structure
666-15
- CAS No.: 1433286-70-4
- Formula:C33H31Cl2N3O5
- Molecular Weight:620.52
IUPAC Name: 3-(3-aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
InChIKey: LELLCPHHYHLWBH-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Cl)C=C1O)C2=CC3=CC=CC=C3C=C2OCCNC(C4=C(OCCCN)C=C(C=CC=C5)C5=C4)=O.Cl
Biological Activity: 666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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666-15 | 99.79% | 666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model. | ||||||||||||||||||||
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666-15 (Standard) | ≥98% | 666-15 (Standard) is the analytical standard of 666-15 (HY-101120). This product is intended for research and analytical applications. 666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model. | ||||||||||||||||||||
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References
- [1]. Xie F, et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87. [Content Brief]
- [2]. Qin Y, et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. Sci Adv. 2020 Feb 19;6(8):eaaw9960. [Content Brief]
